Cathepsin B Rabbit mAb [1XDO]Cat NO.: A16501

Protein names ：CTSB,CPSB,CATB_HUMAN,Cathepsin B [Cleaved into: Cathepsin B light chain,Cathepsin B heavy chain]

UniProtID ：P07858

MASS(da) ：37,822

MW(kDa) ：44kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit IgG

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide of Human Cathepsin B.

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：HepG2 cells.

Function ： Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105)..

Tissue specificity ：Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum..

Subcellular locationi ：Lysosome. Melanosome. Secreted, extracellular space. Apical cell membrane,Peripheral membrane protein,Extracellular side.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.