P-HER3/ErbB3 (Y1289) Rabbit mAb [6ZYR]Cat NO.: A76283

Protein names ：ERBB3,HER3,ERBB3_HUMAN,Receptor tyrosine-protein kinase erbB-3

UniProtID ：P21860

MASS(da) ：148,098

MW(kDa) ：185 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of Human Phospho-HER3/ErbB3 (Tyr1289)

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：T-47D cells treated with neuregulin-1 (100 ng/ml 5 min)

Function ： Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it,ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134). Involved in the regulation of myeloid cell differentiation (PubMed:27416908)..

Tissue specificity ：Epithelial tissues and brain.

Subcellular locationi ：[Isoform 1]: Cell membrane,Single-pass type I membrane protein.,[Isoform 2]: Secreted.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.