SIGIRR Rabbit mAb [WNAS]Cat NO.: A91240

Protein names ：SIGIRR,UNQ301/PRO342,SIGIR_HUMAN,Single Ig IL-1-related receptor

UniProtID ：Q6IA17

MASS(da) ：45,679

MW(kDa) ：46 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human,Mouse,Rat

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide of Human SIGIRR.

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：Fetal kidney tissue lyaste

Function ： Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP..

Tissue specificity ：Mainly expressed in epithelial tissues such as kidney, lung and gut..

Subcellular locationi ：Membrane,Single-pass type III membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.