Cripto1/CRIPTO Rabbit mAb [3277]Cat NO.: A17569

Protein names ：TDGF1,CRIPTO,TDGF1_HUMAN,Teratocarcinoma-derived growth factor 1

UniProtID ：P13385

MASS(da) ：21,169

MW(kDa) ：21 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫荧光(ICC/IF)1:100,
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide of Human Cripto1/CRIPTO.

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：WB cells lyastes

Function ： GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953)..

Tissue specificity ：Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung..

Subcellular locationi ：Cell membrane,Lipid-anchor, GPI-anchor. Secreted.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.