LAMP1 Rabbit mAb [70KZ]Cat NO.: A16699

Protein names ：LAMP1,LAMP1_HUMAN,Lysosome-associated membrane glycoprotein 1

UniProtID ：P11279

MASS(da) ：44,882

MW(kDa) ：90-120kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫荧光(ICC/IF)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of Human LAMP1

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：COS-7 cells

Function ： Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity). Plays also an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.., (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085). Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909).., (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F..

Subcellular locationi ：Cell membrane,Single-pass type I membrane protein. Endosome membrane,Single-pass type I membrane protein. Lysosome membrane,Single-pass type I membrane protein. Late endosome membrane,Single-pass type I membrane protein. Cytolytic granule membrane,Single-pass type I membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.