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CMTM6 Rabbit mAb [J89Z]Cat NO.: A50128

Western blot(SDS-PAGE) analysis of extracts from Rat lung tissue lysate.using CMTM6 Rabbit mAb [J89Z] at dilution of 1:1000 incubated at 4℃ over night.

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Product information

Protein names :CMTM6,CKLFSF6,CKLF6_HUMAN,CKLF-like MARVEL transmembrane domain-containing protein 6

UniProtID :Q9NX76

MASS(da) :20,419

MW(kDa) :22KDa

Form :Rabbit IgG

Purification :Protein A purification

Host :Rabbit

Isotype :IgG

sensitivity :Endogenous

Reactivity : Human,Rat

  • ApplicationDilution
  • 免疫印迹(WB)1:1000-2000
  • The optimal dilutions should be determined by the end user

Specificity :Antibody is produced by immunizing animals with a synthetic peptide of Human CMTM6.

Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected : Rat lung tissue lysate

Function : Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy..

Tissue specificity :Expressed in the leukocytes, placenta and testis..

Subcellular locationi :Cell membrane,Multi-pass membrane protein. Early endosome membrane,Multi-pass membrane protein. Recycling endosome membrane,Multi-pass membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.