P-Nur77 (S351) Rabbit mAb [GWO7]Cat NO.: A17572

Protein names ：NR4A1,GFRP1,HMR,NAK1,NR4A1_HUMAN,Nuclear receptor subfamily 4 group A member 1

UniProtID ：P22736

MASS(da) ：64,463

MW(kDa) ：70-80 kDa

Form ：Liquid

Purification ：Protein A purification

Host ：Rabbit

Isotype ：IgG

sensitivity ：Endogenous

Reactivity ：Human

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with a synthetic peptide at the sequence of Human Phospho-Nur77 (Ser351)

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ： Jurkat cells treated with TPA and calcium ionophore A23187

Function ： Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity)..

Tissue specificity ：Fetal muscle and adult liver, brain and thyroid.

Subcellular locationi ：Nucleus. Cytoplasm. Mitochondrion.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.