PBR Rabbit mAb [AW1N]Cat NO.: A60410

Protein names ：TSPO; PBR; BZRP; IBP; MBR; PKBS; Mitochondrial benzodiazepine receptor; Peripheral benzodiazepine receptor;

UniProtID ：P30536

MASS(da) ：18,828

MW(kDa) ：18kDa

Form ：Liquid

Purification ：Affinity-chromatography

Host ：Rabbit

Isotype ： IgG

sensitivity ：Endogenous

Reactivity ：Human Mouse

• ApplicationDilution
• 免疫印迹(WB)1:1000-2000
• 免疫组化(IHC)1:100
• 免疫荧光(ICC/IF)1:100
• The optimal dilutions should be determined by the end user

Specificity ：Antibody is produced by immunizing animals with A synthesized peptide derived from human PBR

Storage ：Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.

WB Positive detected ：(1) U87-MG cell lysate; (2) A431 cell lysate.

Function ： Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor,can also bind isoquinoline carboxamides (PubMed:1847678)..

Tissue specificity ：Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids..

Subcellular locationi ：Mitochondrion membrane,Multi-pass membrane protein.

IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.