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Western blot(SDS PAGE) analysis of extracts from UACC-62 cells.Using P2X7 Receptor Rabbit mAb [NNL5] at dilution of 1:1000 incubated at 4℃ over night.
Protein names :P2RX7,P2RX7_HUMAN,P2X purinoceptor 7
UniProtID :Q99572
MASS(da) :68,585
MW(kDa) :78 kDa
Form :Liquid
Purification :Protein A purification
Host :Rabbit
Isotype :IgG
sensitivity :Endogenous
Reactivity :Human
Specificity :Antibody is produced by immunizing animals with a synthetic peptide at the sequence of Human P2X7 Receptor
Storage :Antibody store in 10 mM PBS, 0.5mg/ml BSA, 50% glycerol. Shipped at 4°C. Store at-20°C or -80°C. Products are valid for one natural year of receipt.Avoid repeated freeze / thaw cycles.
WB Positive detected : UACC-62 cells
Function : Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206)..
Tissue specificity :Widely expressed with highest levels in brain and immune tissues..
Subcellular locationi :Cell membrane,Multi-pass membrane protein.
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 1% w/v BSA, 1X TBST at 4°C overnight.